Opportunity Information: Apply for RFA AI 24 023
The National Institutes of Health (NIH) is offering a discretionary grant opportunity titled "U.S.-South Africa Program for Collaborative Biomedical Research Phase 3 (HIV/AIDS) (R01 Clinical Trial Optional)" under Funding Opportunity Number RFA-AI-24-023. This program is designed to fund collaborative biomedical research projects that bring together investigators based in South Africa and the United States, with a clear emphasis on true partnership rather than parallel or loosely connected efforts. The aim is to use international collaboration to accelerate scientific discovery, share tools and technical approaches across borders, and generate findings that are directly relevant to local public health needs in South Africa while also contributing to the broader global HIV/AIDS research agenda.
The scientific scope centers on HIV/AIDS and closely related areas that are high priority for patient outcomes and public health impact. NIH is specifically interested in research that addresses HIV/AIDS itself as well as HIV-associated co-morbidities and co-infections, recognizing that many people living with HIV also face intersecting conditions that affect morbidity, mortality, and quality of life. The opportunity also explicitly supports HIV/AIDS-associated implementation science, meaning studies that focus on how evidence-based interventions are adopted, delivered, scaled, and sustained in real-world settings, including health systems and community contexts. In addition, HIV/AIDS-associated data science is included, opening the door for projects involving advanced analytics, modeling, integrated data platforms, and other computational approaches that can strengthen surveillance, optimize interventions, or improve understanding of HIV-related outcomes.
The funding mechanism is an NIH R01, and clinical trials are optional, which means applicants may propose either trials or non-trial studies as long as the overall research plan fits the program goals and NIH requirements. The listed award ceiling is $400,000, indicating the maximum amount allowed under the announcement (applicants would still need to align budgets with the project scope and any NIH budgeting rules for the specific mechanism). While the expected number of awards is not provided in the source information, the opportunity is clearly positioned as a competitive NIH research grant with an emphasis on well-justified, high-impact collaborative projects.
Eligibility is notable and somewhat specific. The announcement indicates that non-domestic (non-U.S.) entities, meaning foreign organizations, are included among eligible applicants (subject to the eligibility criteria described in the full funding opportunity). At the same time, it states that non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply, which is an important distinction for U.S. institutions with international branches or subunits. In practice, this means teams should pay close attention to how the applicant organization and any foreign components are structured and designated in the application, and ensure the partnership model aligns with NIH rules for foreign involvement and the program's intent for U.S.-South Africa collaboration.
Key administrative details include an original application closing date of March 12, 2025, and a creation date of September 17, 2024. The opportunity is associated with multiple CFDA numbers (93.242, 93.273, 93.310, 93.393, 93.399, 93.855, 93.865), reflecting NIH program alignments and funding streams that can support the types of research described. Overall, this NOFO is best understood as a targeted NIH effort to strengthen and advance U.S.-South Africa scientific partnerships focused on HIV/AIDS, spanning biomedical discovery through implementation and data-driven approaches, with the expectation that the collaboration itself is a central feature and a major driver of the proposed project's value.Apply for RFA AI 24 023
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "U.S.-South Africa Program for Collaborative Biomedical Research Phase 3 (HIV/AIDS) (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.273, 93.310, 93.393, 93.399, 93.855, 93.865.
- This funding opportunity was created on 2024-09-17.
- Applicants must submit their applications by 2025-03-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "U.S.-South Africa Program for Collaborative Biomedical Research Phase 3 (HIV/AIDS) (R01 Clinical Trial Optional)."
What is the Funding Opportunity Number (NOFO number)?
The Funding Opportunity Number is RFA-AI-24-023.
Which agency is offering this grant?
The grant is offered by the National Institutes of Health (NIH).
What type of grant mechanism is being used?
This opportunity uses the NIH R01 mechanism.
Are clinical trials required under this opportunity?
No. Clinical trials are optional, meaning applicants may propose either clinical trials or non-trial research, as long as the research plan fits the program goals and NIH requirements.
What is the main purpose of this program?
The program is intended to fund collaborative biomedical research projects that bring together investigators based in South Africa and the United States. A central goal is to support true partnership and integrated collaboration, rather than parallel or loosely connected efforts.
What does NIH mean by a "true partnership" in this program?
Based on the description provided, NIH is emphasizing collaboration that is meaningfully integrated across the South Africa and U.S. teams, with shared scientific goals and joint work that is more than separate projects running side-by-side.
What scientific areas are supported by this opportunity?
The scientific scope centers on HIV/AIDS and closely related areas that are high priority for patient outcomes and public health impact.
Does the opportunity support research on conditions related to HIV/AIDS?
Yes. NIH is specifically interested in research addressing HIV-associated co-morbidities and co-infections, reflecting the reality that people living with HIV may experience intersecting health conditions affecting morbidity, mortality, and quality of life.
Is implementation science within scope?
Yes. The opportunity explicitly supports HIV/AIDS-associated implementation science, including studies on how evidence-based interventions are adopted, delivered, scaled, and sustained in real-world settings such as health systems and community contexts.
Is data science within scope?
Yes. HIV/AIDS-associated data science is included, which can encompass advanced analytics, modeling, integrated data platforms, and other computational approaches that strengthen surveillance, optimize interventions, or improve understanding of HIV-related outcomes.
What is the program trying to achieve through international collaboration?
The stated intent is to accelerate scientific discovery through international collaboration, share tools and technical approaches across borders, and generate findings that are directly relevant to local public health needs in South Africa while also contributing to the broader global HIV/AIDS research agenda.
Is the research expected to be relevant to South Africa?
Yes. The opportunity highlights generating findings directly relevant to local public health needs in South Africa.
Is the research also expected to contribute beyond South Africa?
Yes. The description also notes contribution to the broader global HIV/AIDS research agenda.
Who is eligible to apply?
The announcement indicates that non-domestic (non-U.S.) entities (foreign organizations) are included among eligible applicants, subject to the eligibility criteria described in the full funding opportunity.
Are non-U.S. organizations allowed to apply directly?
Yes, the information provided states that non-domestic (non-U.S.) entities are included among eligible applicants (subject to the NOFO's eligibility criteria).
Are non-domestic components of U.S. organizations eligible to apply?
No. The information provided states that non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply.
Why is the distinction between a foreign organization and a foreign component of a U.S. organization important?
The opportunity notes that foreign organizations may be eligible, but foreign components of U.S. organizations are not eligible to apply. This makes it important for teams to pay close attention to how the applicant organization and any international branches or subunits are structured and designated in the application.
What is the maximum award amount under this opportunity?
The listed award ceiling is $400,000, which is the maximum amount allowed under the announcement.
Does the award ceiling mean every project will receive $400,000?
Not necessarily. The provided information indicates $400,000 is a ceiling (maximum). Applicants are expected to align budgets with the project scope and any applicable NIH budgeting rules for the mechanism.
How many awards does NIH expect to make?
The expected number of awards is not provided in the information supplied for this opportunity.
What is the application deadline?
The original application closing date is March 12, 2025.
When was this funding opportunity created?
The creation date listed is September 17, 2024.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with the following CFDA numbers: 93.242, 93.273, 93.310, 93.393, 93.399, 93.855, and 93.865.
Is this opportunity specifically focused on HIV/AIDS?
Yes. The program is explicitly focused on HIV/AIDS, including HIV-associated co-morbidities, co-infections, implementation science, and data science as they relate to HIV/AIDS.
What kinds of research settings are relevant for implementation-focused projects?
The information provided highlights real-world settings, including health systems and community contexts, for implementation science studies related to HIV/AIDS interventions.
What is the overall positioning of this NOFO?
Based on the description provided, this NOFO is a targeted NIH effort to strengthen and advance U.S.-South Africa scientific partnerships focused on HIV/AIDS, spanning biomedical research through implementation and data-driven approaches, with collaboration itself being a central feature of the proposal's value.
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