Opportunity Information: Apply for PA 16 427
The Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R01) funding opportunity (PA-16-427) is a National Institutes of Health (NIH) discretionary grant program designed to support research that improves how symptoms are prevented, recognized, and treated in people living with HIV who are also dealing with additional health problems. The central focus is on older adults with long-term HIV infection, a group that increasingly faces complex symptom burdens tied not only to HIV itself, but also to HIV-associated Non-AIDS conditions (often referred to as HANA) and other comorbidities that can develop or worsen with aging and prolonged infection. The intent is to move beyond basic descriptions of symptoms and instead fund practical, research-tested approaches that lead to better real-world symptom control and quality of life.
A key theme of this opportunity is innovation paired with cost-effectiveness. Proposed projects are expected to develop, adapt, and test strategies that are feasible to implement in clinical or community settings and that make sense in terms of cost, scalability, and sustainability. The emphasis on symptom management means applicants can propose interventions that help prevent symptoms before they occur, improve early identification and monitoring of symptom patterns, or strengthen clinical and supportive care responses once symptoms appear. Because the targeted population often experiences multiple overlapping conditions, the program is oriented toward approaches that work in the presence of comorbidity rather than assuming a single-disease model. In practical terms, this could include research on new care models, screening and assessment tools, behavioral or supportive interventions, care coordination approaches, technology-assisted symptom tracking, or other strategies aimed at reducing symptom severity, frequency, or impact on daily functioning.
The grant mechanism is the NIH R01, which is commonly used for substantial, hypothesis-driven research projects and typically supports multi-year studies with clearly defined aims, rigorous methods, and meaningful outcomes. The activity category is Education and Health, and the Catalog of Federal Domestic Assistance (CFDA) number associated with this opportunity is 93.361. While the award ceiling and expected number of awards are not specified in the provided source data, the R01 format signals an expectation for well-developed research plans, appropriate study designs (for example, intervention development followed by pilot testing or full-scale trials as appropriate), and strong analytic approaches that can demonstrate whether a symptom management strategy works and for whom it works best.
Eligibility for this opportunity is broad, reflecting NIH's interest in drawing solutions from many sectors. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; and a wide range of nonprofit organizations, including both 501(c)(3) and non-501(c)(3) entities (excluding higher education institutions where specified). For-profit organizations (other than small businesses) and small businesses are also eligible, along with other applicant types. The opportunity also explicitly welcomes applications from organizations that serve or represent specific communities, including Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; regional organizations; U.S. territories or possessions; eligible federal government agencies; and tribal governments that are not federally recognized. Non-domestic (non-U.S.) entities, meaning foreign organizations, are also listed as eligible, which highlights an openness to international perspectives and research settings where relevant.
The opportunity was created on 2016-09-08, and the original closing date listed in the source data is 2018-01-24. As framed, the program is meant to address a growing public health and clinical challenge: people with HIV are living longer, and many are managing multiple chronic conditions at once. This grant supports research aimed at producing practical symptom management strategies that can reduce suffering, improve functioning and well-being, and potentially lessen healthcare utilization by preventing symptoms from escalating into avoidable complications.Apply for PA 16 427
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361.
- This funding opportunity was created on 2016-09-08.
- Applicants must submit their applications by 2018-01-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R01) opportunity?
This is a National Institutes of Health (NIH) discretionary grant program (PA-16-427) that supports research to improve how symptoms are prevented, recognized, and treated in people living with HIV who also have other health conditions (comorbidities).
What is the main goal of this funding opportunity?
The goal is to move beyond simply describing symptom burdens and instead develop, adapt, and test practical, research-backed symptom management approaches that improve real-world symptom control and quality of life for people living with HIV and additional health problems.
Who is the primary population of interest?
The central focus is on older adults with long-term HIV infection, especially those experiencing complex symptom burdens related to HIV, HIV-associated Non-AIDS conditions (HANA), and other comorbidities that can develop or worsen with aging and prolonged infection.
What types of health issues are included under comorbid conditions in this program?
The program targets symptom management in the presence of multiple overlapping conditions, including HIV-associated Non-AIDS conditions (HANA) and other comorbidities that may arise or worsen with aging and long-term HIV infection.
Does the program support basic descriptive studies of symptoms?
The intent is to go beyond basic descriptions of symptoms. Projects should focus on practical, tested strategies that improve symptom control and day-to-day functioning and well-being.
What does "symptom management" mean in the context of this opportunity?
Symptom management can include strategies to prevent symptoms before they occur, improve early identification and monitoring of symptom patterns, or strengthen clinical and supportive care responses once symptoms appear.
What kinds of projects or interventions are encouraged?
Projects may include research on new care models, screening and assessment tools, behavioral or supportive interventions, care coordination approaches, technology-assisted symptom tracking, or other strategies aimed at reducing symptom severity, frequency, or impact on daily functioning.
Is there a focus on innovation and real-world implementation?
Yes. A key theme is innovation paired with cost-effectiveness. Proposed strategies are expected to be feasible in clinical or community settings and to make sense in terms of cost, scalability, and sustainability.
Why does the opportunity emphasize comorbidity rather than a single-disease model?
Because older adults living long-term with HIV often experience multiple overlapping conditions at the same time, the program is oriented toward approaches that work in the presence of comorbidity rather than assuming symptoms can be managed in isolation.
What grant mechanism is used for this program?
The mechanism is an NIH R01 grant, which is commonly used for substantial, hypothesis-driven research projects.
What does the R01 mechanism imply about project scope and design?
The R01 format signals an expectation for well-developed research plans with clearly defined aims, rigorous methods, and meaningful outcomes. The opportunity also references designs such as intervention development followed by pilot testing or full-scale trials, as appropriate.
What outcomes does NIH expect applicants to demonstrate?
Projects are expected to use strong analytic approaches that can show whether a symptom management strategy works and help identify for whom it works best.
What is the activity category for this funding opportunity?
The activity category listed is Education and Health.
What is the CFDA number associated with this opportunity?
The Catalog of Federal Domestic Assistance (CFDA) number is 93.361.
Is the award ceiling listed for this opportunity?
No. The provided information indicates the award ceiling is not specified in the source data.
Is the expected number of awards listed?
No. The provided information indicates the expected number of awards is not specified in the source data.
Who is eligible to apply?
Eligibility is broad and includes many organization types, such as various levels of government, public and private institutions of higher education, tribal governments, public housing authorities, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities, with noted exclusions), for-profit organizations (other than small businesses), small businesses, and other applicant types.
Are state and local governments eligible to apply?
Yes. Eligible applicants include state governments, county governments, and city or township governments, as well as special district governments.
Are colleges and universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal governments eligible?
Yes. Federally recognized Native American tribal governments are eligible, and tribal governments that are not federally recognized are also explicitly welcomed.
Are nonprofit organizations eligible?
Yes. A wide range of nonprofit organizations are eligible, including both 501(c)(3) and non-501(c)(3) nonprofits (excluding higher education institutions where specified).
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) and small businesses are listed as eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly welcomed.
Are minority-serving institutions included among eligible applicants?
Yes. The opportunity explicitly welcomes applications from Alaska Native and Native Hawaiian Serving Institutions; AANAPISIs; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); and Tribally Controlled Colleges and Universities (TCCUs).
Are U.S. territories or possessions included?
Yes. U.S. territories or possessions are among the applicant types explicitly welcomed.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Non-domestic (non-U.S.) entities, meaning foreign organizations, are listed as eligible.
When was this opportunity created?
The opportunity was created on 2016-09-08.
What is the closing date listed in the provided information?
The original closing date listed in the source data is 2018-01-24.
What broader public health issue is this grant trying to address?
It addresses the growing challenge that people with HIV are living longer and often managing multiple chronic conditions at once, creating complex symptom burdens that affect functioning, well-being, and potentially healthcare utilization.
How might successful projects impact healthcare utilization?
By improving symptom management and preventing symptoms from escalating into avoidable complications, effective strategies could potentially lessen healthcare utilization, according to the program description.
Browse more opportunities from the same category: Education, Health
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Previous opportunity: Fiscal Year 2016 Nonprofit Security Grant Program (NSGP)
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 16 427) also looked into and applied for these:
| Funding Opportunity |
|---|
| Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R21) Apply for PA 16 429 Funding Number: PA 16 429 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Encouraging Appropriate Care Using Behavioral Economics through Electronic Health Records (R21/R33) Apply for RFA AG 17 013 Funding Number: RFA AG 17 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Drug Abuse Dissertation Research (R36) Apply for PA 16 443 Funding Number: PA 16 443 Agency: National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| Improving the HIV Pre-Exposure Prophylaxis (PrEP) Cascade (R34) Apply for RFA MH 17 361 Funding Number: RFA MH 17 361 Agency: National Institutes of Health Category: Education, Health Funding Amount: $225,000 |
| Improving the HIV Pre-Exposure Prophylaxis (PrEP) Cascade (R01) Apply for RFA MH 17 360 Funding Number: RFA MH 17 360 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Multi-Site Pilot and Feasibility Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R34) Apply for PAR 16 456 Funding Number: PAR 16 456 Agency: National Institutes of Health Category: Education, Health Funding Amount: $225,000 |
| Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01) Apply for PAR 16 455 Funding Number: PAR 16 455 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Collaborative Consortia for the Study of HIV Associated Cancers: U.S. and Low-and Middle-Income Country Partnerships (U54) Apply for RFA CA 16 018 Funding Number: RFA CA 16 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| National Cancer Institute Program Project Applications (P01) Apply for PAR 16 457 Funding Number: PAR 16 457 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| International Research Scientist Development Award (IRSDA) (K01) Apply for PAR 17 002 Funding Number: PAR 17 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01) Apply for PAR 17 003 Funding Number: PAR 17 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Hepatitis C Virus (HCV) Advanced Molecular Detection in Support of Systems for Prevention, Treatment and Control of HIV, HCV and Related Comorbidities in Rural Communities Affected by Opioid Injection Drug Epidemics in the United States (U24) Apply for RFA DA 17 023 Funding Number: RFA DA 17 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: $370,000 |
| HIV, HCV and Related Comorbidities in Rural Communities Affected by Opioid Injection Drug Epidemics in the United States: Building Systems for Prevention, Treatment and Control (UG3/UH3) Apply for RFA DA 17 014 Funding Number: RFA DA 17 014 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Use of Technology to Enhance Patient Outcomes and Prevent Illness (R21) Apply for PA 17 009 Funding Number: PA 17 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Improving Individual and Family Outcomes through Continuity and Coordination of Care in Hospice (R21) Apply for PA 17 015 Funding Number: PA 17 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Self-Management Interventions and Technologies to Sustain Health and Optimize Functional Capabilities (R01) Apply for PA 17 012 Funding Number: PA 17 012 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Addressing Unmet Needs in Persons with Dementia to Decrease Behavioral Symptoms and Improve Quality of Life (R01) Apply for PA 17 014 Funding Number: PA 17 014 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Addressing Unmet Needs in Persons with Dementia to Decrease Behavioral Symptoms and Improve Quality of Life (R21) Apply for PA 17 013 Funding Number: PA 17 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Self-Management Interventions and Technologies to Sustain Health and Optimize Functional Capabilities (R21) Apply for PA 17 011 Funding Number: PA 17 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Improving Individual and Family Outcomes through Continuity and Coordination of Care in Hospice (R01) Apply for PA 17 016 Funding Number: PA 17 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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