Supporting the provision of person-centered, equitable, high-quality, and integrated service delivery towards a sustainable and resilient HIV/TB response in the Kingdom of Eswatini under PEPFAR | CDC RFA JG 25 0074

Opportunity Information: Apply for CDC RFA JG 25 0074

This funding opportunity is a CDC cooperative agreement under PEPFAR focused on strengthening HIV and TB service delivery in Eswatini in a way that is person-centered, equitable, high-quality, and better integrated at the point of care. The program is intended to support site-level HIV/TB prevention, care, and treatment services while aligning closely with Eswatini's national vision for a sustainable HIV/TB response and PEPFAR's 2023-2028 Five-Year Strategy. The overall thrust is not just maintaining services, but improving how they are delivered, making them more responsive to patient needs, more consistent in quality, and more connected across clinical areas so clients experience a coordinated pathway rather than fragmented services.

Funding details are somewhat unusual at first glance: the posted Year 1 award ceiling is listed as 0 (none), but CDC anticipates an approximate total of $4,000,000 available in Fiscal Year funding for Year 1, contingent on the availability of funds. CDC expects to make about three awards. Because this is a cooperative agreement, applicants should expect substantial CDC involvement in planning, implementation support, and performance monitoring compared to a standard grant. The opportunity is listed as discretionary funding in the health category under CFDA 93.067, and it is broadly open to many applicant types, including government entities, public and private colleges and universities, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses), tribal governments and organizations, and other unrestricted applicants.

Programmatically, the award is designed to reinforce both demand for services and the delivery of those services. On the demand side, that typically means strengthening approaches that help people seek and remain in care, reducing access barriers, and working with communities to improve awareness, trust, and uptake. On the delivery side, the work emphasizes implementing national guidelines correctly and consistently, fostering innovation in how services are organized and delivered, and pushing for practical integration of HIV and TB services at the facility level. Integration here implies that HIV and TB prevention, screening, diagnosis, treatment, follow-up, and support services should function as a cohesive package where possible, rather than being siloed into separate workflows that increase missed opportunities and patient burden.

A core expectation is continuous quality improvement and stronger use of data for decision-making. The opportunity highlights maintaining quality and improving effective data use, which often translates into strengthening routine monitoring, improving data completeness and timeliness, using data to identify gaps in coverage or performance, and acting on those insights through targeted mentorship and operational changes. It also signals that support may need to be hands-on and operational, not only technical. CDC specifically notes that more intensive logistical and technical support may be required to prevent service disruptions, particularly in higher-risk areas such as laboratory diagnostic services, commodity management (for example, ensuring test kits and medications are available when and where needed), and health information system implementation. In practice, this points to a strong emphasis on systems that keep clinics functioning reliably: supply chains, specimen transport and lab networks, inventory controls, and digital or routine reporting systems.

A major outcome built into the design of the notice of funding opportunity is a planned transition over the course of the award. The expectation is that the intensity of external support should gradually decrease as service delivery, key response functions, and clinical mentorship are transferred to the Ministry of Health and/or other local entities. That means applicants should be prepared to show how they will build local capacity from the start, shift responsibilities in a deliberate way, and avoid creating parallel systems that are difficult to sustain. Even though investments should prioritize HIV/TB interventions, CDC also signals that these investments should be adaptable to broader public health goals, suggesting a preference for strengthening platforms and capabilities (workforce, labs, data systems, supply chains, quality improvement) that can serve multiple health priorities over time.

Geographically, the work is expected to concentrate in the Manzini and Lubombo regions, but awardees must have the ability to operate across all regions as needed. The approach is also expected to be collaborative and community-informed. CDC explicitly calls for meaningful engagement with stakeholders, community organizations, beneficiaries, and affected communities, which indicates that community input should not be a box-checking exercise but a driver of how interventions are selected, tailored, and evaluated. This requirement fits with the person-centered and equitable framing of the opportunity, where services should reflect lived realities, address disparities, and respond to barriers faced by populations most affected by HIV and TB.

Key administrative details include the opportunity number CDC RFA JG 25 0074, with an original closing date of 2025-03-05 and a creation date of 2024-12-17. Overall, the opportunity is aimed at ensuring Eswatini's HIV/TB services remain resilient, integrated, and high-performing in the near term while deliberately moving toward local ownership and sustainability in line with national priorities and PEPFAR's strategy for 2023-2028.

• The Centers for Disease Control-GHC in the health sector is offering a public funding opportunity titled "Supporting the provision of person-centered, equitable, high-quality, and integrated service delivery towards a sustainable and resilient HIV/TB response in the Kingdom of Eswatini under PEPFAR" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
• This funding opportunity was created on 2024-12-17.
• Applicants must submit their applications by 2025-03-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• The number of recipients for this funding is limited to 3 candidate(s).
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Unrestricted.

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