Opportunity Information: Apply for RFA HL 18 010
The Basic Research in Calcific Aortic Valve Disease (R01) funding opportunity (RFA-HL-18-010) is a discretionary grant program from the U.S. Department of Health and Human Services through the National Institutes of Health, focused on advancing foundational science related to calcific aortic valve disease (CAVD). Its central goal is to spur innovative molecular and physiological studies that can move the field toward two major clinical needs: earlier diagnosis of CAVD and the development of effective medical (non-surgical) therapies. In practical terms, this FOA is aimed at research that helps explain the underlying mechanisms of valve calcification and disease progression, and that can point to measurable early indicators or targets for intervention.
A distinctive feature of this announcement is its explicit encouragement of cross-disciplinary ideas and teams. The NIH highlights that investigators who may not traditionally identify as CAVD researchers are strongly encouraged to apply if their expertise can be brought to bear on the problem. Examples called out include mineralization and bone physiology (given the parallels between pathological calcification and bone-related pathways), extracellular matrix physiology (important because valve structure, stiffness, and remodeling are tightly linked to disease progression), and molecular imaging (relevant for detecting early changes, tracking calcification activity, and potentially enabling earlier clinical decision-making). This framing signals that the program values new perspectives, toolsets, and mechanistic frameworks that can unlock progress in a disease area where treatment options have historically been limited.
The funding mechanism is the NIH R01, a standard research project grant intended to support hypothesis-driven, investigator-initiated work. The award ceiling is listed as $250,000, and the opportunity anticipated making about 5 awards. The announcement was created on May 17, 2017, with an original closing date of October 18, 2017. While those dates indicate the specific competition window for this FOA, the program description still clearly communicates the type of science NIH wanted to stimulate: basic research with a credible line of sight to translational relevance, particularly in enabling early detection strategies or identifying therapeutic targets that could ultimately reduce the need for valve replacement procedures.
Eligibility is broad and includes many types of organizations that commonly conduct biomedical research. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities, other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and Native American tribal governments and tribal organizations, including federally recognized tribal governments. Public housing authorities and Indian housing authorities are also listed as eligible, along with an "Other" category referencing additional eligibility details in the full text. The activity category is Health, and the associated CFDA number is 93.837, aligning it with NIH heart, lung, and blood research areas.
Overall, this FOA is best understood as an NIH-driven push to strengthen the fundamental science pipeline for CAVD by funding mechanistic and physiology-centered research that can produce actionable insights for diagnostics and therapeutics. It emphasizes novelty and interdisciplinary participation, reflecting the belief that solving CAVD will require both deeper biological understanding and the importation of methods and concepts from adjacent fields like bone biology, matrix biology, and advanced imaging.Apply for RFA HL 18 010
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Basic Research in Calcific Aortic Valve Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837.
- This funding opportunity was created on May 17, 2017.
- Applicants must submit their applications by Oct 18, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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