Opportunity Information: Apply for RFA HL 18 010
The Basic Research in Calcific Aortic Valve Disease (R01) funding opportunity (RFA-HL-18-010) is a discretionary grant program from the U.S. Department of Health and Human Services through the National Institutes of Health, focused on advancing foundational science related to calcific aortic valve disease (CAVD). Its central goal is to spur innovative molecular and physiological studies that can move the field toward two major clinical needs: earlier diagnosis of CAVD and the development of effective medical (non-surgical) therapies. In practical terms, this FOA is aimed at research that helps explain the underlying mechanisms of valve calcification and disease progression, and that can point to measurable early indicators or targets for intervention.
A distinctive feature of this announcement is its explicit encouragement of cross-disciplinary ideas and teams. The NIH highlights that investigators who may not traditionally identify as CAVD researchers are strongly encouraged to apply if their expertise can be brought to bear on the problem. Examples called out include mineralization and bone physiology (given the parallels between pathological calcification and bone-related pathways), extracellular matrix physiology (important because valve structure, stiffness, and remodeling are tightly linked to disease progression), and molecular imaging (relevant for detecting early changes, tracking calcification activity, and potentially enabling earlier clinical decision-making). This framing signals that the program values new perspectives, toolsets, and mechanistic frameworks that can unlock progress in a disease area where treatment options have historically been limited.
The funding mechanism is the NIH R01, a standard research project grant intended to support hypothesis-driven, investigator-initiated work. The award ceiling is listed as $250,000, and the opportunity anticipated making about 5 awards. The announcement was created on May 17, 2017, with an original closing date of October 18, 2017. While those dates indicate the specific competition window for this FOA, the program description still clearly communicates the type of science NIH wanted to stimulate: basic research with a credible line of sight to translational relevance, particularly in enabling early detection strategies or identifying therapeutic targets that could ultimately reduce the need for valve replacement procedures.
Eligibility is broad and includes many types of organizations that commonly conduct biomedical research. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities, other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and Native American tribal governments and tribal organizations, including federally recognized tribal governments. Public housing authorities and Indian housing authorities are also listed as eligible, along with an "Other" category referencing additional eligibility details in the full text. The activity category is Health, and the associated CFDA number is 93.837, aligning it with NIH heart, lung, and blood research areas.
Overall, this FOA is best understood as an NIH-driven push to strengthen the fundamental science pipeline for CAVD by funding mechanistic and physiology-centered research that can produce actionable insights for diagnostics and therapeutics. It emphasizes novelty and interdisciplinary participation, reflecting the belief that solving CAVD will require both deeper biological understanding and the importation of methods and concepts from adjacent fields like bone biology, matrix biology, and advanced imaging.Apply for RFA HL 18 010
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Basic Research in Calcific Aortic Valve Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837.
- This funding opportunity was created on May 17, 2017.
- Applicants must submit their applications by Oct 18, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQ)
What is the name of this funding opportunity?
The opportunity is titled Basic Research in Calcific Aortic Valve Disease (R01) and is identified as RFA-HL-18-010.
Which agency is offering this grant?
This is a discretionary grant program from the U.S. Department of Health and Human Services (HHS) through the National Institutes of Health (NIH).
What disease area is the program focused on?
The FOA focuses on calcific aortic valve disease (CAVD), with an emphasis on understanding valve calcification and disease progression at a foundational (basic research) level.
What is the main goal of this FOA?
The central goal is to advance foundational science that can help move the field toward two major clinical needs: earlier diagnosis of CAVD and the development of effective medical (non-surgical) therapies.
What kinds of research does NIH want to stimulate under this announcement?
The FOA is aimed at innovative molecular and physiological studies that explain underlying mechanisms of valve calcification and disease progression, while maintaining a credible connection to translational relevance (such as identifying early indicators or therapeutic targets).
Does the FOA emphasize basic research or clinical trials?
Based on the description provided, the emphasis is on basic research (mechanistic and physiology-centered work) rather than primarily clinical research, while still encouraging research directions that can inform diagnostics and therapies.
What are the two major clinical needs this research is intended to support?
The FOA explicitly highlights: (1) earlier diagnosis of CAVD and (2) effective medical (non-surgical) therapies that could ultimately reduce reliance on valve replacement procedures.
Is interdisciplinary research encouraged?
Yes. A distinctive feature of this announcement is its explicit encouragement of cross-disciplinary ideas and teams, including investigators who may not traditionally identify as CAVD researchers.
Can researchers outside the traditional CAVD field apply?
Yes. The NIH explicitly notes that investigators who do not typically identify as CAVD researchers are strongly encouraged to apply if their expertise can be applied to the problem.
What example disciplines does the FOA specifically call out as relevant?
The announcement highlights examples including mineralization and bone physiology, extracellular matrix physiology, and molecular imaging as areas that may bring valuable concepts and tools to CAVD research.
Why are mineralization and bone physiology considered relevant to CAVD?
The FOA points to parallels between pathological calcification in valves and bone-related pathways, suggesting that insights from mineralization and bone physiology may help explain mechanisms driving valve calcification.
Why is extracellular matrix physiology relevant to this program?
Because valve structure, stiffness, and remodeling are tightly linked to disease progression, extracellular matrix physiology is highlighted as important for understanding how the valve environment changes as CAVD advances.
Why does the FOA mention molecular imaging?
Molecular imaging is described as relevant for detecting early changes, tracking calcification activity, and potentially enabling earlier clinical decision-making related to CAVD.
What funding mechanism is used for this opportunity?
The funding mechanism is the NIH R01, described as a standard research project grant intended to support hypothesis-driven, investigator-initiated work.
What is the award ceiling mentioned in the FOA?
The award ceiling is listed as $250,000.
How many awards were anticipated?
The FOA anticipated making about 5 awards.
When was the announcement created?
The announcement was created on May 17, 2017.
What was the original closing date for this FOA?
The original closing date is listed as October 18, 2017.
What does the FOA suggest about the type of outcomes NIH wants from funded projects?
The description emphasizes basic research that can yield actionable insights for diagnostics and therapeutics, such as explaining mechanisms of calcification, identifying measurable early indicators, or pointing to targets for intervention.
What category of activity does this program fall under?
The activity category is Health.
What is the CFDA number associated with this opportunity?
The associated CFDA number is 93.837, aligning it with NIH heart, lung, and blood research areas.
Which types of organizations are eligible to apply?
Eligibility is broad and includes: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3), other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; Native American tribal governments (including federally recognized) and tribal organizations; public housing authorities; Indian housing authorities; and an "Other" category referencing additional eligibility details in the full text.
Are small businesses eligible?
Yes. Small businesses are explicitly listed as eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed separately as eligible.
Are nonprofit organizations eligible?
Yes. The FOA lists nonprofit organizations including 501(c)(3) and non-501(c)(3) entities (other than institutions of higher education).
Are universities and colleges eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are government entities eligible?
Yes. Eligible applicants include state, county, city or township governments, plus special district governments and independent school districts.
Are tribal governments and tribal organizations eligible?
Yes. The FOA lists Native American tribal governments (including federally recognized tribal governments) and tribal organizations as eligible.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are included in the eligibility list.
What does the "Other" eligibility category mean?
The FOA includes an "Other" category that references additional eligibility details in the full text, indicating there may be further specifics beyond the summarized list.
How should this FOA be understood overall?
Overall, it is an NIH effort to strengthen the fundamental science pipeline for CAVD by funding mechanistic research with a clear line of sight to translational relevance, while explicitly valuing novelty and interdisciplinary participation.
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